Clinically reviewed by Dr. Pipat Finn, M.D., Senior Doctor, Doctor Pattaya.
Last reviewed: August 2026
Doxycycline 100mg twice daily for seven days is the first-line treatment for chlamydia in 2026. It clears the infection in the vast majority of patients when taken correctly and completed in full. If you are in Pattaya, Doctor Pattaya can test and prescribe on the same visit, seven days a week, any time of day.
You had a good few days in Pattaya. Maybe it got a little wild. Now something feels off, and you are quietly searching symptoms at your hotel in Pratumnak at midnight hoping it is nothing. It might well be nothing. But if there is any chance you picked up chlamydia, you are in the right place.
Chlamydia is one of the most common infections we treat here, and it is very treatable. One short antibiotic course, taken correctly, clears it in most people. This article covers what you will be prescribed, how to take it safely while you are still out here in the Thai sun, what side effects to watch for, and what to do if something still does not feel right when the course ends.

Why Doxycycline Is Now the First-Line Choice for Chlamydia
A few years ago, a single large dose of azithromycin was the standard go-to. Simple, one pill and done. The problem is that the evidence shifted. Major treatment guidelines moved doxycycline to first-line after data showed azithromycin had meaningfully higher failure rates, particularly in men and in rectal infections. Doxycycline now has the stronger track record.
We follow those same guidelines here. When patients come into Doctor Pattaya with confirmed or clinically suspected chlamydia, doxycycline is what we prescribe. Azithromycin still has a role in specific situations, but for most patients, doxycycline is the right call. You can read more about how we approach STD treatment in Pattaya, including how we choose between antibiotics depending on your situation.
The Standard Dose and How Long It Takes to Work
The dose is 100mg twice daily for seven days. One tablet in the morning, one in the evening, roughly twelve hours apart. The course must be completed in full, even if you feel better after three or four days.
Most patients notice symptoms improving within the first few days. Some mild discharge or discomfort can linger briefly even after successful treatment, as the tissue heals. That is normal. What is not normal is symptoms that are unchanged or getting worse after the full course ends. Come back in if that happens.

Does the Site of Infection Change Your Treatment?
For genital chlamydia, seven days of doxycycline is standard regardless of gender. For rectal chlamydia from anal sex, doxycycline is also the clear preference, and the evidence shows it outperforms azithromycin for rectal infections by a significant margin. This matters clinically given the population we see in Pattaya.
If your symptoms are more severe than typical chlamydia, or involve significant rectal pain, swollen glands in the groin, or ulceration, mention that at your consultation. A more aggressive strain called LGV requires a 21-day course rather than seven, and it needs to be identified correctly upfront.
Sun, Sea, and Doxycycline: A Real Warning for Pattaya
This is the section most generic websites skip over. Doxycycline makes your skin more sensitive to UV light. Under northern European sun, that is a mild concern. Under Thailand’s UV levels, during peak beach hours in Pattaya or down at Jomtien, it is a genuine risk of a phototoxic burn that can come on much faster than a normal sunburn.
Wear SPF 50 or higher every morning without fail. Cover your shoulders and back on the beach. Stay out of direct sun between 10am and 3pm where you can. A hat and a light cover-up make a real difference. This is not a reason to delay treatment. It is just something you need to know before you head out for the day.
How to Take Doxycycline Correctly
Take each tablet with a full glass of water. Stay upright, sitting or standing, for at least thirty minutes after each dose. Lying down too soon can let the tablet sit in your food pipe and cause irritation there, which is painful and completely avoidable.
Food helps with nausea. A light meal with each dose is fine. What you must avoid near the time of each dose: dairy products, antacids, calcium supplements, and iron supplements. These reduce how well the drug is absorbed. Space them at least two hours away from your doxycycline.
If you miss a dose, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and carry on. Do not take two at once.
What If You Have More Than One Infection?
Chlamydia and gonorrhoea frequently show up together. We see co-infections regularly at the clinic. Doxycycline treats chlamydia well but does not reliably cover gonorrhoea on its own. If your test comes back positive for both, or if gonorrhoea is suspected based on your symptoms, you will need an additional antibiotic alongside the doxycycline.
This is another reason testing properly matters more than guessing and self-medicating. Our chlamydia and gonorrhoea testing screens for both at the same visit, so nothing gets missed.
Side Effects Worth Knowing About
Nausea and stomach upset are the most common. The food and posture advice above reduces them significantly. Photosensitivity is the most practically important one for anyone spending time outdoors in Pattaya. Oesophageal irritation is avoidable if you stay upright and drink enough water. Headache and mild dizziness can occur but are usually short-lived.
Serious allergic reactions are rare. If you develop difficulty breathing, significant facial swelling, or a rapidly spreading rash after taking the medication, come straight in or go directly to the nearest emergency department.
Drug Interactions and Precautions
If you take a combined oral contraceptive pill, there is a possible interaction with its effectiveness. Use a barrier method throughout the seven-day course and for seven days after it ends. Tell the doctor at your consultation what medications and supplements you take so nothing gets overlooked.
Doxycycline is not safe in pregnancy. If there is any possibility you are pregnant, tell us at the consultation. There are alternative treatments we can use safely.
After Treatment: Abstinence, Retesting, and Your Partner
Do not have sex, including with a condom, until seven days after your last dose and your partner has also been treated. Reinfection is the most common reason symptoms return after a completed course, and this window is how you prevent it.
Get retested at three months. Even after successful treatment, reinfection is common if partners are not treated or new exposures occur. A three-month retest is worth doing regardless of how you feel.
Tell your recent partners. It is an uncomfortable conversation, but it matters. Untreated chlamydia can lead to serious complications, and telling someone gives them the chance to get sorted. That is the right thing to do.
What to Expect at the Clinic in Pattaya
Walk in any time. No appointment needed. We take a brief history covering your symptoms and recent contacts, collect a urine sample or swab depending on the infection site, and talk through your options at the same visit.
For many patients, we can prescribe doxycycline at the same consultation based on clinical assessment, without waiting for lab results. When lab confirmation is needed, we walk you through the timeline and follow up with you directly. Everything is confidential. Nobody here is judging you. We deal with this every single day.
If you think you may have chlamydia, or you want to get tested after a risk exposure in Pattaya, Doctor Pattaya’s clinic is open 24 hours a day, seven days a week in South Pattaya. Walk in or contact us to arrange a hotel visit to your room in Pattaya, Jomtien, or Naklua. We offer confidential STD testing and same-visit prescriptions for chlamydia treatment, including doxycycline where clinically appropriate. Get sorted today and get back to your trip.


